- Scholarship in 2016 at Max Planck Institute for Biophysical Chemistry
Chun So (Nick) received his B.Sc. in Cell and Molecular Biology (CMB) (first-class honour) from the CUHK and his Dr. rer. nat. in Physics of Biological and Complex Systems (summa cum lauda) at the Georg-August-Universität Göttingen.
Interested in both chemistry and biology, he gained his first two lab experience at the CUHK under the supervision of Prof KS Chan and Prof Tsang during his high school education at the La Salle College. By the time of the release of HKDSE results, he made a tough decision between studying chemistry, biology and medicine. At last, he decided to go for the new, appealing, research-oriented CMB programme at the CUHK.
During his undergraduate study, he received 15 awards and scholarships including the Swire Scholarship 2013-2016 and the Fung Scholarship 2015-2016, covering all of his tuition fees and expenses. Apart from studying during the term time, he followed Prof Tsang again in his sophomore year and conducted almost-full-time research in her lab. In the past three years, he received excellent guidance from Prof Tsang and led a research project on the molecular and cellular mechanisms linking diabetes and breast cancer. He also collaborated with other labmates on studying reverse apoptosis in breast cancer cells and the roles of different TRP channels in mouse embryonic stem cells and cardiac differentiation.
Before making another critical decision in his life, that is, what to study for his PhD, he exposed himself to many different fields in life sciences. By the end of his freshman year, he joined Prof PC Shaw's lab under the SMART program and studied novel proteins of influenza A virus. Later in the summer of his freshman year, he was selected into the Study Abroad Program in Shanghai co-organized by the Harvard University and the Fudan University, working on epithelial-mesenchymal transition in hepatocellular carcinoma in Prof LX Qin's lab. In the summer of his sophomore year, he enrolled in the UROPS of the National University of Singapore and examined small RNAs in neural development in Prof QD Hu's lab. In the summer of his junior year, he was chosen as one of the six students from China in the NDM Summer Internship Programme of the University of Oxford. Under the guidance of Prof L Dorrell, he was exceptionally allowed to work in the containment level 3 facility and helped developing novel T cell receptor-based HIV therapy. In a collaboration between Prof. L Dorrell and Dr N Ternette, he used cutting-edge proteomics to investigate the kinetics of HIV protein during early infection as well. After his B.Sc. graduation in May 2016 and before starting his PhD in July 2016, he participated in the TIGP IIP at the Academia Sinica and studied yeast's pre-mRNA splicing in Dr SC Cheng's lab.
Being heavily exposed to different areas of developmental biology, it is not particularly surprising that Nick continued his PhD study on even earlier developmental events at the Department of Meiosis, where he followed Dr M Schuh to develop new tools for studying meiosis in different mammalian eggs, including human. Here, he would like to thank the Croucher Foundation again for funding his exciting PhD study in Goettingen, Germany. Currently, he is doing a follow-up postdoc at the Department of Meiosis.
For more information on his previous and current work, please kindly refer to the following publications:
Chan YW*, So C*, Yau KL, Chiu KC, Wang X, Chan FL, Tsang SY. Adipose-derived stem cells and cancer cells fuse to generate cancer stem cell-like cells with increased tumorigenicity. J Cell Physiol. (in press)
So C*, Seres KB*, Steyer AM, Mönnich E, Clift D, Pejkovska A, Möbius W, Schuh M. A liquid-like spindle domain promotes acentrosomal spindle assembly in mammalian oocytes. Science. 2019 Jun;364(6447):eaat9557. (*equal contribution)
Xu Y, So C, Lam HM, Fung MC, Tsang SY. Flow cytometric detection of newly-formed breast cancer stem cell-like cells after apoptosis reversal. J Vis Exp. 2019 Jan;(143).
Clift D*, So C*, McEwan WA, James LC, Schuh M. Acute and rapid degradation of endogenous proteins by Trim-Away. Nat Protoc. 2018 Oct;13(10):2149-2175. (*equal contribution)
Xu Y, So C, Lam HM, Fung MC, Tsang SY. Apoptosis reversal promotes cancer stem cell-like cell formation. Neoplasia. 2018 Mar;20(3):295-303.
Yang H, Buisson S, Bossi G, Wallace Z, Hancock G, So C, Ashfield R, Vuidepot A, Mahon T, Molloy P, Oates J, Paston SJ, Aleksic M, Hassan N, Jakobsen BK, Dorrell L. Elimination of HIV-1 reservoir cells from antiretroviral therapy-suppressed subjects by engineered immune-mobilising T cell receptors. Mol Ther.2016 Nov; 24(11):1913-1925.
Lo IC, Chan HC, Qi Z, Ng KL, So C, Tsang SY. TRPV3 channel negatively regulates cell cycle progression and safeguards the pluripotency of embryonic stem cells. J Cell Physiol. 2016 Feb;231(2):403-13.
Qi Y, Qi Z, Li Z, Wong CK, So C, Lo IC, Huang Y, Yao X, Tsang SY. Role of TRPV1 in the differentiation of mouse embryonic stem cells into cardiomyocytes. PLoS One. 2015 Jul;10(7):e0133211.