Kok-Lung (Chris) Chan

  • Fellowship in 2007 at the University of Oxford
  • Scholarship in 2003 at the University of Oxford

Dr. Kok-Lung (Chris) Chan obtained his B.Sc. (first-class honours) in Biotechnology and M.Phil. in Pathology in the University of Hong Kong. He was awarded the Croucher Scholarship and Overseas Research Scheme (ORS) Scholarship to read his D.Phil. in Molecular Medicine in University of Oxford. In 2007, he was also awarded the Croucher Fellowship to conduct research on chromosome segregation in Oxford. Chris was then awarded Sir Henry Dale Fellowship from Wellcome Trust and the Royal Society in 2014 and started his own research group in MRC Genome Damage and Stability Centre in UK.

Currently

Dr. Chris Kok-Lung Chan's research focus is on the maintenance of genome integrity, especially on how replicated chromosomes are faithfully segregated during cell division. He discovered a novel DNA structure named 'ultrafine-DNA bridges' in mitotic cells. His current research is focusing on how replicated DNA is cohesed and timely resolved during mitosis.

Selected Publications:

1. Mus81 promotes common fragile site expression.

Ying S*, Minocherhomji S*, Chan KL*, Palmai-Pallag T, Chu WK, Wass T, Mankouri HW, Liu Y, Hickson ID (*co-authors)

Nat Cell Bio (2013), 15(8): 1001-7

2. Cohesin’s DNA exit gate is distinct from its entrance gate and is regulated by acetylation.

Chan KL*, Roig MB*, Hu B*, Beckouet F, Metson J, Nasmyth K (*co-authors)

Cell (2012), 150(5): 961-74

3. Replication stress induces sister-chromatid bridging at fragile site loci in mitosis.

Chan KL, Palmai-Pallag T, Ying S, Hickson ID

Nat Cell Bio (2009), 11(6): 753-60

4. The Bloom’s syndrome helicase is required for faithful chromosome segregation and its localization defines a novel class of anaphase bridges.

Chan KL, North SP, Hickson ID

EMBO J (2007), 26(14):3397-409 (This article is featured in Nature (2007), 448(7151): 228)