Wai-Lung (Billy) Ng 吳濰龍

  • Fellowship in 2014 at University of Oxford

Dr Wai-Lung (Billy) Ng obtained his B.Sc. degree in Chemistry (1st Class Hons.) and Ph.D. in Chemistry from the Chinese University of Hong Kong (CUHK). During his graduate study, he was a Fulbright Scholar at Massachusetts Institute of Technology (MIT), under the generous funding supports from the Lee Hysan Foundation and the Fulbright Program. From 2014 – 2016, he joined the University of Oxford as a Croucher Foundation Postdoctoral Fellow. He was then recruited to Harvard Medical School / Dana-Farber Cancer Institute as a research fellow from 2016 – 2019. 

Dr Ng has a strong interest in understanding diseases on the molecular basis with a goal to develop tools to diagnose and treat them. His Ph.D. research centers on the syntheses of a new class of anti-diabetic agents, namely sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors. His research works [1][2][3] have already led to the identification of several stable, potent and selective SGLT2 inhibitors that may provide an alternative solution for treating diabetes.

At Oxford, he developed several chemical protein modification reactions, such as “post-translational mutagenesis” for studying post-translational modifications of proteins [4], a site-selective radical reaction for incorporating fluorine tag into proteins [5], and a site-selective strategy for creating deuterated proteins [6]. At Harvard, he focused on the identification of new drug targets and therapeutic molecules for the treatment of lung cancer [7][8].

Currently

Dr Ng joined CUHK as an assistant professor in 2019, with a research focus on chemical biology, drug discovery, and medicinal chemistry. The Ng lab aims at developing novel small-molecule inhibitors for the treatment of various diseases, including cancers, neurodegenerative and infectious diseases [9][10]. For more details, please refer to Ng Lab's homepage: https://www.ngwailung.com/

His interview by the Croucher Foundation can be found here: https://projects.croucher.org.hk/news/making-molecules

Press release about his discoveries can be found here: http://www.cpr.cuhk.edu.hk/en/press_detail.php?id=2399

Reference:

[1] Angew. Chem. Int. Ed., 2013, 52, 8401.

[2] Angew. Chem. Int. Ed., 2016, 55, 13818.

[3] Sci. Rep., 2017, 7, 5581.

[4] Science, 2016, 354, 597.

[5] J. Am. Chem. Soc., 2018, 140, 1568.

[6] Nat. Chem. Bio., 2018, 14, 955.

[7] Cancer Discov., 2020, 10, 270.

[8] Cancer Res, 2020, Published OnlineFirst. DOI: 10.1158/0008-5472.CAN-19-3782

[9] Mol. Cell, 2020, DOI: https://doi.org/10.1016/j.molcel.2020.07.027

[10] bioRxiv, 2020, DOI: https://doi.org/10.1101/2020.05.26.116020