Will Lee

  • Senior Research Fellowship in 2002 at the The University of Hong Kong


Professor Lee has been working on the cell and molecular biology of blood-tissue barrier.  He is using mammalian testis as a model.  The human testis is able to produce 200 million of sperm per day.  He is keen to disclose the two mysteries about mammalian spermatogenesis -- how are germ cells translocated across the blood-testis barrier without affecting the barrier functions and how are different events of spermatogenesis coordinated to give a timely process?  The blood-testis barrier is one of the tightest blood-tissue barriers in mammals.  It poses a challenge to deliver any drugs to the testis.  To circumvent this problem, his group has launched study to use a genetically-engineered follicle-stimulating-hormone mutant as a testis-specific carrier, conjugating to an occludin peptide, to transiently open the blood-testis barrier for drug delivery.  This effect is limited to the blood-testis barrier without compromising the barrier integrity in other organs. The device will lead similar studies on targeted drug delivery across other blood-tissue barriers and likewise to develop efficient way to increase drug uptake in the intestine.