Alex Che Chun Tsui

Alex Che Chun Tsui 徐梓畯

Alex is currently reading his joint DPhil & PhD degrees at the University of Oxford, working with Prof. Mark Sansom, before relocating to Scripps Research (California) in 2020 working with Prof Andrew Ward. Alex receives his major funding from the prestigious Skaggs-Oxford Scholarship, with additional support from the Croucher Foundation. He graduated with a MSc ETH in Biology (Structural Biology & Biophysics) from the Swiss Federal Institute of Technology Zurich (ETH Zürich). Prior to that, he read a BSc in Biochemistry at University College London with First Class Honours (Dean's List) and was the top of the class.

Alex has developed a strong interest in Structural Biology & Biophysics since his final year of undergraduate. He carried out his Undergraduate Research Project at Prof. Carolyn Moores' lab at Birkbeck, University of London investigating a microtubule-interacting protein. Alex also worked on other microtubule cytoskeleton projects during summer vacations, with Dr Thomas Surrey's group at Cancer Research UK London (now The Francis Crick Institute) and with Dr Etsuko Muto's group at RIKEN Brain Science Institute in Tokyo.

For his Master's Thesis, Alex joined Prof Martin Pilhofer's lab at ETH Zürich where he gained further insights to cryo-electron microscopy – a rapidly advancing Structural Biology technique that he has consuming passion for. In brief, cryo-EM permits the determination of large protein assemblies in high (atomic) resolution. This sheds light to how proteins and drugs interact at the molecular level, for instance.

Alex enjoys wine tasting, cooking, hiking and photography in his free time. He recently attained the WSET Level 3 (Advanced) Award in Wines.

Current work

Alex's joint research project at Oxford and Scripps investigates the structure, lipid interactions, and mechanism of mammalian mechanically activated ion channels. The aim is to use molecular modelling and simulation to aid and extend the interpretation and analysis of intermediate resolution structures determined by cryo-electron microscopy. A particular focus is on characterising the nature of lipid interactions with channel in order to better understand the mechanism of mechanical coupling between the channel and the surrounding lipid bilayer. This will help to define these channels as possible pharmaceutical targets. The project involves molecular dynamics simulations, statistical and thermodynamic analysis of simulation data, and analysis and refinement of cryo-electron microscopy derived structures.

Publications:

  1. Jojoa-Cruz S, Saotome K, Murthy SE, Tsui CCA, Sansom MSP, Patapoutian A, Ward AB. Cryo-EM structure of the mechanically activated ion channel OSCA1.2. eLife 7, e41845 (2018). https://doi.org/10.7554/eLife.41845

News Articles Related to Research Work:

  1. Scientists find mysterious family of proteins are cellular pressure sensors – Scripps Research
  2. Deciphering the role of mechanosensitive proteins – Croucher Foundation