- Studentship in 2022 at Hong Kong University of Science and Technology
About Chan Tsz Ching’s work
Chan Tsz Ching works in the field of aging, and is researching the role of histone modification on aging in mouse muscle stem cells. She is focused on identifying the histone post-translational modification (PTM) hallmarks and histone-modifying proteins that are altered in satellite cells (SCs) during aging, and assessing their importance in SCs aging.
Chan’s hypothesis is that restoring the expressions and activities of histone-modifying proteins in aged SCs could facilitate the rejuvenation of SCs, restore muscle regeneration, and help extend the healthy lifespan. Chan will use single cell RNA sequencing (scRNA-seq) and Single-cell sequencing assay for transposase-accessible chromatin (scATAC-seq) between rejuvenated and aged SCs to determine histone PTM hallmarks through differential expression and chromatin accessibility patterns. Mass spectrometry-based proteomics will also be applied to assess the genome-wide changes of epigenetics marks on histones.
Understanding the histone modifying proteins that participate in SC aging provides novel therapeutic targets to reverse aging, treat and prevent aging-associated diseases, and potentially extend the healthy life span of an organism.
Biography
Chan Tsz Ching is doing her PhD in the Division of Life Science at Hong Kong University of Science and Technology. She was previously in the International Research Enrichment Track while taking a BSc in Biochemistry and Cell Biology at HKUST. She has previously been awarded the D. H. Chen Foundation Life Science Scholarship, an AEON Credit Service Scholarship, the University's Scholarship Scheme for Continuing Undergraduate Students, and a Hong Kong Women Professionals & Entrepreneurs Association WISE Scholarship.