- Croucher Cambridge International Scholarship in 2014 at University of Cambridge
Daniel Shiu-Hin Chan completed his BSc (Advanced Science) degree at the University of Sydney, Australia and his BSc (Honours I) degree in Chemistry at the University of New South Wales, Australia, under the supervision of Prof. Naresh Kumar and Prof. David StC. Black.
He has also worked as a Research
Assistant at the Department of Chemistry at the University of Hong Kong and then at the Department of Chemistry at the Hong Kong Baptist University
under the supervision of Dr. Dik-Lung (Edmond) Ma and Dr. Chung-Hang (Duncan) Leung.
CurrentlyDaniel is currently pursuing his PhD studies under the supervision of Prof. Chris Abell at the Department of Chemistry at the University of Cambridge. His research centers around the use of mass spectrometry to aid fragment-based drug discovery.
As of 2020, his PhD research has contributed to 11 publications:
1. D. S.-H. Chan (first author), J. Hess, E. Shaw, C. Spry, R. Starley, C. Dagostin, M. V. B. Dias, R. Kale, V. Mendes, T. L. Blundell, A. G. Coyne, C. Abell. Structural insights into Escherichia coli phosphopantothenoylcysteine synthetase by native ion mobility–mass spectrometry. Biochem. J. 2019, 476, 3125.
2. D. S.-H. Chan (first author), M. E. Kavanagh, K. McLean, A. Munro, D. M.-V. Vinković, A. G. Coyne, C. Abell. Effect of DMSO on protein structure and interactions assessed by collision-induced Dissociation and Unfolding. Anal. Chem., 2017, 89, 9976.
3. D. S.-H. Chan (first author), V. Mendes, S. E. Thomas, B. N. McConnell, D. M.-V. Vinković, A. G. Coyne, T. L. Blundell, C. Abell. Fragment screening against the EthR-DNA interaction by native mass spectrometry. Angew. Chem. Int. Ed., 2017, 56, 7488 (chosen as a “Hot Paper” by the Editors for its importance in a rapidly evolving field of high current interest, rated as “Highly/Very Important” by all three referees; highlighted by ChemViews Magazine, chemistryviews.org/details/ezine/10560326/.html; highlighted by Practical Fragments, http://practicalfragments.blogspot.co.uk/2017/07/native-mass-spectrometry-revisited.html).
4. D. S.-H. Chan (first author), W.-G. Seetoh, B. N. McConnell, D. M.-V. Vinković, S. E. Thomas, V. Mendes, M. Blaszczyk, A. G. Coyne, T. L. Blundell, C. Abell. Structural insights into the EthR–DNA interaction using native mass spectrometry. Chem. Commun., 2017, 53, 3527.
5. D. S.-H. Chan (first author), A. J. Whitehouse, A. G. Coyne, C. Abell. Mass spectrometry for fragment screening. Essays Biochem., 2017, 61, 465.
6. D. S.-H. Chan (first author), D. M.-V. Vinković, A. G. Coyne, C. Abell. Insight into protein conformation and subcharging by DMSO from native ion mobility mass spectrometry. ChemistrySelect, 2016, 1, 5686.
7. A. Trapero, A. Pacitto, D. S-H. Chan, C. Abell, T. L. Blundell, D. B. Ascher, A. G. Coyne. Covalent inactivation of Mycobacterium thermoresistibile inosine-5′-monophosphate dehydrogenase (IMPDH). Bioorg. Med. Chem. Lett. 2020, 30, 126792.
8. A. J. Whitehouse, S. E. Thomas, K. P. Brown, A. Faourakis, D. S.-H. Chan, M. D. J. Libardo, V. Mendes, H. I. M. Boshoff, R. A. Floto, C. Abell, T. L. Blundell, A. G. Coyne. Development of Inhibitors against Mycobacterium abscessus tRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches. J. Med. Chem. 2019, 62, 15, 7210.
9. C. Marchetti, D. S.-H. Chan, A. G. Coyne, C. Abell. Fragment-based approaches to TB drugs. J. Parasitol., 2018, 145, 184.
10. W.-G. Seetoh, D. S.-H. Chan, D. M.-V. Vinković, C. Abell. Mass spectrometry reveals protein kinase CK2 high-order oligomerization via the circular and linear assembly. ACS Chem. Biol., 2016, 11, 1511.
11. M. E. Kavanagh, A. G. Coyne, K. J. McLean, G. G. James, C. W. Levy, L. B. Marino, L. P. S. de Carvalho, D. S.-H. Chan, S. A. Hudson, S. Surade, D. Leys, A. W. Munro, C. Abell. Fragment-based approaches to the development of Mycobacterium tuberculosis CYP121 inhibitors. J. Med. Chem., 2016, 59, 3272.