Josephine Lai

Scholarship in 1983 at Imperial College London

Publications

2014

Discovery of amphipathic dynorphin A analogues to inhibit the neuroexcitatory effects of dynorphin A through bradykinin receptors in the spinal cord.

2013

Truncation of the peptide sequence in bifunctional ligands with mu and delta opioid receptor agonist and neurokinin 1 receptor antagonist activities.

Effect of anchoring 4-anilidopiperidines to opioid peptides.

2012

Activation of descending pain-facilitatory pathways from the rostral ventromedial medulla by cholecystokinin elicits release of prostaglandin-E₂ in the spinal cord.

2011

Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands.

Currently

Research Interests:

Molecular mechanisms of neuropathic pain; opioid receptor pharmacology; gene targeting, drug discovery.